Actually, the 'bugs' are only there as a metaphor to real crazy people who have the common symptom of 'bugs' crawling on them.SPOILER ALERT!!!!!The entire movie takes place inside the woman's mind. The motel room represents her sub-conscience. The bad boyfriend represents the devil on her shoulder always trying to get her to do wrong. The girlfriend represents the counter-balance of good & evil. Each character who enters the room represents a different emotion of her sub-conscience as she slowly becomes Skitso! Remember the phone call at the beginning (and repeated at the end)? That's when she found out her son had died. After that she goes into Pcychosis and thus the 'movie inside her mind' begins. Also, notice that anytime there are more than 2 characters in the motel room the 3rd one and 2nd one never acknowledge each other? Because it's all in the woman's head. Then, they show the phone call again at the end and it takes us right back to the moment the story began. This time we don't know if she's better or if she's going to repeat her psychosis. Strange movie but better the 3rd or 4th time....lol